Living With CFRespiratory DiseaseTreatments

Risk of Hearing Loss from IV Aminoglycosides in Cystic Fibrosis

Cumulative exposure to IV tobramycin and amikacin, which are critical for treating cystic fibrosis infections, increases the risk of hearing loss. A study, “The cumulative effects of intravenous antibiotic treatments on hearing in patients with cystic fibrosis,” published last month in the Journal of Cystic Fibrosis discusses how IV tobramycin, …

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Living With CFResearchRespiratory Disease

Respiratory Health and Air Pollution

The impact of small particle air pollution on the lower airways (lungs) has long been studied, but now scientists have evidence of its negative impact on the upper sinonasal airways as well. The World Health Organization’s recommendation for small particle air pollution (PM2.5) is that it not exceed an average …

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GeneticsLiving With CFRespiratory DiseaseTreatments

Does Ivacaftor Affect Lung Bacteria in Cystic Fibrosis?

Ivacaftor has been shown to increase CFTR activity and lung function in people with Cystic Fibrosis and the G551D mutation, but until a recent study, scientists were not sure if ivacaftor changed the level of bacteria in the lungs. The results of a deeper study on ivacaftor have been published, …

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ExerciseLiving With CFResearchRespiratory Disease

Research on CF and Exercise in Cystic Fibrosis treatment

Significant research, both recent and decades old, shows that exercise helps people with CF. Yet it’s not always a part of a person’s Cystic Fibrosis treatment regimen. Here are some facts that may convince you to exercise more with the the guidance and approval of your CF team. “Exercise can …

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Living With CFResearchRespiratory Disease

Cystic Fibrosis Lung Microbiome: Diversity and Lung Function

The article, The Lung Microbiome and Airway Disease, published September 2016 in the Annals of the American Thoracic Society, describes various research studies that analyzed the relationship between the lung microbiome and airway disease in Cystic Fibrosis. Scientists can now better examine microbial communities in the lungs, and they are …

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Living With CFResearchRespiratory DiseaseTreatments

CFTR Function and Cigarette Smoke

Scientists are looking at how the CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) potentiator, Ivacaftor, might be used in COPD, specifically chronic bronchitis. They found that cigarette smoking reduces CFTR activity in lung tissue, and that exposing the lung cells directly to a CFTR potentiator reverses this effect. While the vast …

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Living With CFResearchRespiratory Disease

The Lung Microbiome and Dysbiosis

The “microbiome” is a hot topic in respiratory medicine, with researchers from diverse fields such as chronic obstructive pulmonary disease, bronchiectasis, pulmonary fibrosis, and lung transplantation seeking to use the newly accessible technology of bacterial ribosomal RNA sequencing and related technologies to characterize airway bacterial communities and to determine the …

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Living With CFResearchRespiratory DiseaseVideo

Webinar: Infection Prevention During Bronchoscopy

Laurence Muscarella Ph.D. and Atul Mehta M.D. A detailed webinar (71:30 minutes) can be viewed online. Highlights: The latest research into bronchoscope cross-contamination issues. Most frequent causes of infection risks Most importantly:  what everyone who uses bronchoscope should know to prevent risks Click to view the Webinar    

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Living With CFResearchRespiratory Disease

Copper in Hospitals to Limit Cross-Infection

The use of copper in hospital rooms, may reduce cross-infection, a common concern in cystic fibrosis centers. Using copper on high-touch surfaces in hospitals may reduce Hospital-Acquired-Infections, according to a report published in the American Journal of Infection Control. The New York Times article describing this report says: …on average, …

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Living With CFResearchRespiratory Disease

Distinguishing Relapse from Reinfection in MAC

MAC is a non-tuberculosis mycobacterium (NTM). It is found everywhere in the environment, and since the 1990s has been increasingly found in people with Cystic Fibrosis. In the News A study was published this month in the Annals of the American Thoracic Society (ATS) that looked at the differences between …

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